AuthorsH. Radhakrishnan, and S. C. Kassinos
EditorsO. Dössel, and W. C. Schlegel
TitleNumerical Modeling of Turbulent Airflow and Particle Deposition in a Bifurcating Airway Model
Afilliation, Scientific Computing
Project(s)Center for Biomedical Computing (SFF)
StatusPublished
Publication TypeProceedings, refereed
Year of Publication2010
Conference NameWorld Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany
Volume25
Pagination2089-2092
PublisherSpringer Berlin Heidelberg
ISBN Number978-3-642-03882-2
Abstract

Understanding transport and deposition of inhaled particles in the human airways plays a crucial role in the targeted therapy of pulmonary diseases, and the administration of inhaled medicines. Numerous researchers have studied the inhalation of particles using experiments or computer models. Even though experiments have shown that the airflow in the trachea and the upper branches of the lung is turbulent, the flow is taken to be laminar in most computer models. Only few recently published papers have looked at the turbulent transport of air in the human airways. Even fewer results have been published on the effect of the upper airway structures on the turbulent airflow in the lungs or on the effect of the turbulence on particle deposition. The previously published turbulent models have also mainly used RANS methods to predict the flow. To study the unsteady flow and particle deposition in a human lung, an LES model with a dynamic Smagorinsky sub-grid scale model was used. The model equations were solved to study steady inspirational flow at different flow rates for different particle sizes. Results indicate that the upper airway geometry produces turbulence in the flow and the deposition of particles is mainly affected by the particle size and Stokes number.

Notes

Is listed in 2009 annual report

DOI10.1007/978-3-642-03882-2\_554
Citation KeySimula.sc.1008