Dry eye disease (DED) has a prevalence of between 5 and 50%, depending on the diagnostic criteria used and population under study. However, it remains one of the most underdiagnosed and undertreated conditions in ophthalmology. Many tests used in the diagnosis of DED rely on an experienced observer for image interpretation, which may be considered subjective and result in variation in diagnosis. Since artificial intelligence (AI) systems are capable of advanced problem solving, use of such techniques could lead to more objective diagnosis. Although the term ‘AI’ is commonly used, recent success in its applications to medicine is mainly due to advancements in the sub-field of machine learning, which has been used to automatically classify images and predict medical outcomes. Powerful machine learning techniques have been harnessed to understand nuances in patient data and medical images, aiming for consistent diagnosis and stratification of disease severity. This is the first literature review on the use of AI in DED. We provide a brief introduction to AI, report its current use in DED research and its potential for application in the clinic. Our review found that AI has been employed in a wide range of DED clinical tests and research applications, primarily for interpretation of interferometry, slit-lamp and meibography images. While initial results are promising, much work is still needed on model development, clinical testing and standardisation.

Subjective user studies are important to ensure the fidelity and usability of systems that generate multimedia content. Testing how end-users and domain experts perceive multimedia assets might provide crucial information. In this paper, we present our experiences with the open source hybrid crowdsourced-remote user survey framework called Huldra, which is intended for conducting web-based subjective user studies and aims to integrate the individual benefits associated with traditional, crowdsourced, and remote methods. We disseminate our experiences and insights from two actively deployed use cases and discuss challenges and opportunities associated with using Huldra as a framework for conducting user studies.

Recent global developments underscore the prominent role big data have in modern medical science. But privacy issues constitute a prevalent problem for collecting and sharing data between researchers. However, synthetic data generated to represent real data carrying similar information and distribution may alleviate the privacy issue. In this study, we present generative adversarial networks (GANs) capable of generating realistic synthetic DeepFake 10-s 12-lead electrocardiograms (ECGs). We have developed and compared two methods, named WaveGAN* and Pulse2Pulse. We trained the GANs with 7,233 real normal ECGs to produce 121,977 DeepFake normal ECGs. By verifying the ECGs using a commercial ECG interpretation program (MUSE 12SL, GE Healthcare), we demonstrate that the Pulse2Pulse GAN was superior to the WaveGAN* to produce realistic ECGs. ECG intervals and amplitudes were similar between the DeepFake and real ECGs. Although these synthetic ECGs mimic the dataset used for creation, the ECGs are not linked to any individuals and may thus be used freely. The synthetic dataset will be available as open access for researchers at OSF.io and the DeepFake generator available at the Python Package Index (PyPI) for generating synthetic ECGs. In conclusion, we were able to generate realistic synthetic ECGs using generative adversarial neural networks on normal ECGs from two population studies, thereby addressing the relevant privacy issues in medical datasets.

The coefficient of determination, the R2, is often used to measure the variance explained by an affine combination of multiple explanatory covariates. An attribution of this explanatory contribution to each of the individual covariates is often sought in order to draw inference regarding the importance of each covariate with respect to the response phenomenon. A recent method for ascertaining such an attribution is via the game theoretic Shapley value decomposition of the coefficient of determination. Such a decomposition has the desirable efficiency, monotonicity, and equal treatment properties. Under a weak assumption that the joint distribution is pseudo-elliptical, we obtain the asymptotic normality of the Shapley values. We then utilize this result in order to construct confidence intervals and hypothesis tests for Shapley values. Monte Carlo studies regarding our results are provided. We found that our asymptotic confidence intervals required less computational time to competing bootstrap methods and are able to exhibit improved coverage, especially on small samples. In an expository application to Australian real estate price modeling, we employ Shapley value confidence intervals to identify significant differences between the explanatory contributions of covariates, between models, which otherwise share approximately the same R2 value. These different models are based on real estate data from the same periods in 2019 and 2020, the latter covering the early stages of the arrival of the novel coronavirus, COVID-19.