Meibomian gland dysfunction is the most common cause of dry eye disease, which is a prevalent condition that can damage the ocular surface and cause reduced vision and substantial pain. Meibum secreted from the meibomian glands makes up the majority of the outer, protective lipid layer of the tear film. Changes in the secreted meibum and markers of glandular damage can be detected through tear sampling.
Several studies have investigated the tear film protein expression in meibomian gland dysfunction, but less work apply machine learning to analyze the protein patterns. We use machine learning and methods from explainable artificial intelligence to detect potential clinically relevant proteins in meibomian gland dysfunction. Two different explainable artificial intelligence methods are compared. Several of the proteins found important in the models have been linked to dry eye disease in the past, while some are novel. Consequently, explainable artificial intelligence methods serve as a promising tool for screening for proteins that are relevant for meibomian gland dysfunction. By doing so, one may be able to discover new biomarkers and treatments, and gain a better understanding of how diseases develop.

Nowadays, most people have a smartphone that can track their everyday activities. Furthermore, a significant number of people wear advanced smartwatches to track several vital biomarkers in addition to activity data. However, it is still unclear how these data can actually be used to improve certain aspects of people’s lives. One of the key challenges is that the collected data is often massive and unstructured. Therefore, a link to other important information (e.g., when, what, and how much food was consumed) is required. It is widely believed that such detailed and structured longitudinal data about a person is essential to model and provide personalized and precise guidance. Despite the strong belief of researchers about the power of such a data-driven approach, respective datasets have been difficult to collect. In this study, we present a unique dataset from two individuals performing a structured data collection over eight and a half months. In addition to the sensor data, we collected their nutrition, training, and well-being data. The availability of nutrition data with many other important objectives and subjective longitudinal data streams may facilitate research related to food for a healthy lifestyle. Thus, we present a sport, nutrition, and lifestyle logging dataset called ScopeSense from two individuals and discuss its potential use. The dataset is fully open for researchers, and we consider this study as a potential starting point for developing methods to collect and create knowledge for a larger cohort of people.

In association football, the development of multimodal summaries is of great importance to both broadcasters and spectators since a large number of viewers choose to follow just the soccer game highlights. The fundamental drive for the development of summarization systems is the requirement to manage huge amounts of data in different formats. By highlighting the most pertinent facts and limiting or omitting unnecessary aspects, summarization helps avoid "information overload." The properties of the audio signals during a particular event can be used to calculate excitement around that event and filter events based on their importance. A root-mean-square (RMS) analysis of audio events was carried out to analyse the excitement across the events in the SoccerNet dataset. It was clearly seen that important events with excitement have a high and distinguishable RMS audio intensity. It was also observed that the generated noise of the crowd was significantly different across various events and if it happened for the home or away team. The intensity was higher for events related to the home team. Likewise, as the wavelet has the benefit of integrating a wave with a specific period, Morlet wavelet analysis was performed for various event types, and the power of the signal across various wavelet scales was analyzed. A distinct signature across various wavelet scales was observed for different events.

The in vitro fertilization procedure called intracytoplasmic sperm injection can be used to help fertilize an egg by injecting a single sperm cell directly into the cytoplasm of the egg. In order to evaluate, refine and improve the method in the fertility clinic, the procedure is usually observed at the clinic. Alternatively, a video of the procedure can be examined and labeled in a time-consuming process. To reduce the time required for the assessment, we propose an unsupervised method that automatically clusters video frames of the intracytoplasmic sperm injection procedure. Deep features are extracted from the video frames and form the basis for a clustering method. The method provides meaningful clusters representing different stages of the intracytoplasmic sperm injection procedure. The clusters can lead to more efficient examinations and possible new insights that can improve clinical practice. Further on, it may also contribute to improved clinical outcomes due to increased understanding about the technical aspects and better results of the procedure. Despite promising results, the proposed method can be further improved by increasing the amount of data and exploring other types of features.

This paper contains the research proposal of Andrea M. Storås that was presented at the MMSys 2022 doctoral symposium. Machine learning models have the ability to solve medical tasks with a high level of performance, e.g., classifying medical videos and detecting anomalies using different sources of data. However, many of these models are highly complex and difficult to understand. Lack of interpretability can limit the use of machine learning systems in the medical domain. Explainable artificial intelligence provides explanations regarding the models and their predictions. In this PhD project, we develop machine learning models for automatic analysis of medical data and explain the results using established techniques from the field of explainable artificial intelligence. Current research indicate that there are still open issues to be solved in order for end users to understand multimedia systems powered by machine learning. Consequently, new explanation techniques will also be developed. Different types of medical data are applied in order to investigate the generalizability of the methods.

Tacrolimus is one of the cornerstone immunosuppressive drugs in most transplantation centers worldwide following solid organ transplantation. Therapeutic drug monitoring of tacrolimus is necessary in order to avoid rejection of the transplanted organ or severe side effects. However, finding the right dose for a given patient is challenging, even for experienced clinicians. Consequently, a tool that can accurately estimate the drug exposure for individual dose adaptions would be of high clinical value. In this work, we propose a new technique using machine learning to estimate the tacrolimus exposure in kidney transplant recipients. Our models achieve predictive errors that are at the same level as an established population pharmacokinetic model, but are faster to develop and require less knowledge about the pharmacokinetic properties of the drug.

Ubiquitous sensors and Internet of Things (IoT) technologies have revolutionized the sports industry, providing new methodologies for planning, effective coordination of training, and match analysis post game. New methods, including machine learning, image and video processing, have been developed for performance evaluation, allowing the analyst to track the performance of a player in real-time. Following FIFA's 2015 approval of electronics performance and tracking system during games, performance data of a single player or the entire team is allowed to be collected using GPS-based wearables. Data from practice sessions outside the sporting arena is being collected in greater numbers than ever before. Realizing the significance of data in professional soccer, this paper presents video analytics, examines recent state-of-the-art literature in elite soccer, and summarizes existing real-time video analytics algorithms. We also discuss real-time crowdsourcing of the obtained data, tactical and technical performance, distributed computing and its importance in video analytics and propose a future research perspective.
 

Dry eye disease (DED) has a prevalence of between 5 and 50%, depending on the diagnostic criteria used and population under study. However, it remains one of the most underdiagnosed and undertreated conditions in ophthalmology. Many tests used in the diagnosis of DED rely on an experienced observer for image interpretation, which may be considered subjective and result in variation in diagnosis. Since artificial intelligence (AI) systems are capable of advanced problem solving, use of such techniques could lead to more objective diagnosis. Although the term ‘AI’ is commonly used, recent success in its applications to medicine is mainly due to advancements in the sub-field of machine learning, which has been used to automatically classify images and predict medical outcomes. Powerful machine learning techniques have been harnessed to understand nuances in patient data and medical images, aiming for consistent diagnosis and stratification of disease severity. This is the first literature review on the use of AI in DED. We provide a brief introduction to AI, report its current use in DED research and its potential for application in the clinic. Our review found that AI has been employed in a wide range of DED clinical tests and research applications, primarily for interpretation of interferometry, slit-lamp and meibography images. While initial results are promising, much work is still needed on model development, clinical testing and standardisation.

Widely used traditional supervised deep learning methods require a large number of training samples but often fail to generalize on unseen datasets. Therefore, a more general application of any trained model is quite limited for medical imaging for clinical practice. Using separately trained models for each unique lesion category or a unique patient population will require sufficiently large curated datasets, which is not practical to use in a real-world clinical set-up. Few-shot learning approaches can not only minimize the need for an enormous number of reliable ground truth labels that are labour-intensive and expensive, but can also be used to model on a dataset coming from a new population. To this end, we propose to exploit an optimization-based implicit model agnostic meta-learning (iMAML) algorithm under few-shot settings for medical image segmentation. Our approach can leverage the learned weights from diverse but small training samples to perform analysis on unseen datasets with high accuracy. We show that, unlike classical few-shot learning approaches, our method improves generalization capability. To our knowledge, this is the first work that exploits iMAML for medical image segmentation and explores the strength of the model on scenarios such as meta-training on unique and mixed instances of lesion datasets. Our quantitative results on publicly available skin and polyp datasets show that the proposed method outperforms the naive supervised baseline model and two recent few-shot segmentation approaches by large margins. In addition, our iMAML approach shows an improvement of 2%–4% in dice score compared to its counterpart MAML for most experiments.